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Figure 4. Inhibition is inversely proportional to the level of cAMP-mediated activation of CFTR: (a) An example trace shows the graded nature of CFTR channel function where total cellular current increases with increasing IBMX concentration. Maximum current was defined as that which was elicited by 1 mM IBMX + 50 μM FSK. (b) Summary data show the fractional current elicited with each activation condition. (c) Summary traces show the distinct kinetics associated with inhibition of channels by 1 μg/mL SMase following activation with 0.01, 0.1, or 1.0 mM IBMX (n = 4–5). (d) Summary data showing that fractional inhibition at 10 minutes was dependent upon activation condition (p = 0.0003, 1-way ANOVA). Image published in: Stauffer BB et al. (2017) © The Author(s) 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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