Xenbase Image ID: 170649

Fig. 6. Rostral shifting and expansion of somitomere and presomitic mesoderm markers occurs in Rarβ2 MO-injected embryos. (A-F) Embryos were injected unilaterally at the 2- or 4-cell stage with 26 ng Rarβ2.L MO+26 ng Rarβ2.S MO. Injected side is indicated by magenta β-gal lineage tracer. Neurula stage embryos shown in dorsal view with anterior on the left. Rarβ2 MOs rostrally shift somitomere markers Ripply2 (A) and Mespa/Thyl2 (B), and thicken their boundaries of expression (Ripply2, 25/27 embryos; Mespa, 26/ 31). The expression domains of presomitic mesoderm markers Tbx6 (C), Msgn1 (D) and Fgf8 (E), and the Notch direct target Esr5 (F) are expanded rostrally (red vertical lines) by Rarβ2 MOs (Tbx6, 26/28 embryos; Msgn1, 7/9; Fgf8, 9/13; Esr5, 19/20). Broken red line indicates the midline. Image published in: Janesick A et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue ripply2.1.L ledgerline, stripy X. laevis Throughout NF stage 16 presomitic mesoderm caudal presomitic mesoderm mespa.L hen2, mespa-a, mespa-b, thy2, thyl1, thyl2, thylacine 1, thylacine 2, thylacine1, thylacine2 X. laevis Throughout NF stage 16 presomitic mesoderm caudal presomitic mesoderm tbx6.L XTbx6 X. laevis Throughout NF stage 16 presomitic mesoderm msgn1.L mes1, mesogenin, MesP-related bHLH factor, Mespo, msgn1-a, msgn1-b, pMesogenin1 X. laevis Throughout NF stage 16 presomitic mesoderm fgf8.L AIGF, FGF-8, fgf-8b, fgf8a, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. laevis Throughout NF stage 16 presomitic mesoderm esr-5.L ESR 5, esr5, LOC108703524, x-esr5, Xesr5 X. laevis Throughout NF stage 16 presomitic mesoderm caudal presomitic mesoderm Image source: Published Larger Image Printer Friendly View

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