XB-IMG-170651
Xenbase Image ID: 170651
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Fig. 8. Summary of RARβ2 loss-of-function phenotypes and RARβ2-
mediated regulation of Tbx6 and Tbx3 in somitogenesis and hypaxial
myoblast migration. Xenopus Rarβ2 is the RAR subtype most upregulated in
response to ligand. The localization of Rarβ2 in the trunk somites positions it to
respond to RA and control somitogenesis. RARβ2 regulates somite chevron
morphology, restricts the PSM anterior boundary and promotes hypaxial
myoblast migration. RARβ2 loss of function yields fewer and larger somites,
often with disorganized or blurred domains. Ripply2 converts Tbx6 to a
transcriptional repressor in vivo, but does not influence Tbx3 transcriptional
activity. RARβ2 positively regulates Tbx3 to promote hypaxial muscle migration
and negatively regulates Tbx6 to restrict the PSM and caudal progenitor pool. Image published in: Janesick A et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |