Xenbase Image ID: 170666

Fig. 1. Xenopus mesendoderm gene regulatory network from fertilization through early-gastrula. The network is comprised of 35 TFs and 12 growth factors. Maternal proteins are represented as diamonds, and signaling ligands as circles. Connections are drawn from the transcriptional regulator to the cis-regulatory region of the target gene, and direct connections are indicated as solid lines and putative connections as dashed lines. Connections from secreted ligands pass through a chevron and are mediated by their respective intracellular TFs (e.g. Smad2/3, Ctnnb1/β-catenin). Approximate spatiotemporal information is provided from top to bottom (egg through early-gastrula) and from right to left (dorsal to ventral), with some exceptions (e.g. t/bra). The activation time of zygotic sox7 (boxed) is unknown. All direct connections are annotated for TF binding (blue diamond), reporter assay (pink diamond), and TF binding plus functional validation (maroon diamond). For additional connection details, including experimental evidence and references, see Table 1 and Table S2. ZGA, zygotic genome activation. Image published in: Charney RM et al. (2017) Copyright © 2017. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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