Xenbase Image ID: 170725

Figure 7. Pcdh15 knockdown in X. tropicalis causes distinct morphological alterations to the rod and cone outer segments and the associated calyceal processes (TEM analyses). (A) In longitudinal (left) and transverse (right) thin sections, control rod photoreceptors have the expected shape, with cylindrical, multilobed outer segments (OS). The calyceal processes (CPs) can be seen all around the OS, lying within (black arrowheads) and occasionally between incisures demarcating the lobes of the rod disks (see diagram). The base of the OS is congruent with the tip of the inner segment (IS; left, arrow). (B) In morphant larvae, several rods display an enlarged base (boxed areas), which TEM analysis revealed to consist of packets of outgrown disks extending well beyond the IS–OS interface and folding laterally. These outgrown disks are confined within the boundaries of the delimiting incisures (white arrowheads). The CPs are visible adjacent to the unaffected region but not adjacent to the basal enlargements of the OS (middle and right). Bars, 1 µm. Image published in: Schietroma C et al. (2017) © 2017 Schietroma et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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