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Figure 6. Effects of the arylsulfonamide compound AqB011 on ionic current responses in oocytes expressing different classes of AQPs. (A) Responses were recorded for control (DMSO vehicle), and AtPIP2;1, AtPIP2;2, and HsAQP1 expressing oocytes before (left) and after 2 h incubation (right) in AqB011 at the indicated doses. HsAQP1 was blocked by 20 μM AqB011; AtPIP2;1 and AtPIP2;2 currents were not affected by 100 μM AqB011. (B) Box plot summary of the conductance levels before and after treatment with AqB011. **** (p < 0.0001); NS (not significant); using ANOVA with post hoc Bonferroni tests; n values are below the x-axis. Image published in: Kourghi M et al. (2017) © 2017 by the authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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