Xenbase Image ID: 170734

Figure 7. Amino acid sequence alignment of HsAQP1, RnAQP4, RnAQP5, AtPIP2;1, AtPIP2;2, AtPIP2;7 and DmBIB. Sequences from the NCBI Protein Database were aligned using Clustal Omega software (Available online: http://www.ebi.ac.uk/Tools/msa/clustalo/; accessed on 18 October 2017). HsAQP1 protein topology was from the Topology Data Bank of Transmembrane Proteins (TOPDB). Symbols: asterisk (*) identical residues across all sequences; colon (:) highly conserved residue; period (.) semi-conserved residue. Hyphens (-) show gaps; black vertical lines separate predicted domains, as labelled. Colors illustrate chemical properties: positive charged (magenta), negative charged (blue), polar (green), hydrophobic (red). Highlighted in yellow are NPA (Asn-Pro-Ala) signature motifs located in loops B and E, conserved in most aquaporins. The carboxy terminus of DmBIB was truncated for this figure. Image published in: Kourghi M et al. (2017) © 2017 by the authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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