XB-IMG-170838
Xenbase Image ID: 170838
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Figure 6. Model for MMR-Mediated ICL Repair
ICLs can be recognized and repaired in the absence of replication. The MutSα complex senses and binds ICL lesions and recruits downstream repair proteins including the MutLα endonuclease, PCNA, and EXO1 exonuclease. The ICL lesion is repaired through a multi-step excision resynthesis reaction. The latter requires Polκ and monoubiquitinated PCNA. Image published in: Kato N et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |