Xenbase Image ID: 171222

Figure 5. NLS β-Catenin Rescues foxj1 Transcription and LR Patterning Defects in Rapgef5 Morphants Depletion of Rapgef5 reduces the expression of the Wnt responsive gene foxj1 and alters LR patterning (pitx2c). Red arrow indicates an example of normal pitx2c expression on the left side of the embryo. Co-injection of 50 pg of NLS-β-catenin mRNA significantly rescues (A) expression of foxj1 at stage 10 and (B) pitx2c expression in Rapgef5 depleted embryos. ∗p < 0.05, ∗∗p < 0.01. Image published in: Griffin JN et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue foxj1 foxj1-a, foxj1-b, hfh-4, hfh4, xfoxj1 X. tropicalis Throughout NF stage 10 dorsal marginal zone pitx2 pitx2-A, pitx2-a, pitx2-b, pitx2c, xpitx2, xPtx2 X. tropicalis Throughout NF stage 28 left cement gland trigeminal placode Image source: Published Larger Image Printer Friendly View

Return to previous page