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Figure S5. Related to Fig. 6; Developmental expression of Rapgef5 and Rap
genes. In situ hybridization reveals rapgef5 mRNA is present from the earliest stages
of development. It is detected in the animal pole at the 2 cell and 8 cell stages. In the
stage 10 embryos expression appears diffuse around the blastopore. At stage 14
transcripts are detected in the anterior neural folds and forming GRP. rapgef5
expression is restricted to the anterior neural tube, brain, pharyngeal arches and
cranial placodes at stage 28. rap1A, rap2A and rap2B are all expressed in the 4 cell
embryo, in the gastrulating stage 10 embryo and in the GRP at stage 16. Expression
of all three genes is also strong in the neural folds at stage 16, while rap2B also
displays a speckled pattern on the lateral ectoderm. All three are expressed in the
neural tube, brain, eye and pharyngeal arches at stage 28.
Image published in: Griffin JN et al. (2018)
Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V.
Gene | Synonyms | Species | Stage(s) | Tissue |
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rapgef5 | | X.tropicalis | Throughout NF stage 2 (2-cell) | blastomere
| rapgef5 | | X.tropicalis | Throughout NF stage 4 (8-cell) | animal blastomere
| rapgef5 | | X.tropicalis | Throughout NF stage 10 | | rapgef5 | | X.tropicalis | Throughout NF stage 14 | gastrocoel roof plate pre-chordal neural plate border
| rapgef5 | | X.tropicalis | Throughout NF stage 28 | anterodorsal lateral line placode epibranchial placode glossopharyngeal epibranchial placode facial epibranchial placode central nervous system spinal cord pharyngeal arch branchial arch otic vesicle
| rap1a | rap1, krev1, krev-1 | X.tropicalis | Throughout NF stage 3 (4-cell) | blastomere
| rap1a | rap1, krev1, krev-1 | X.tropicalis | Throughout NF stage 10 | | rap1a | rap1, krev1, krev-1 | X.tropicalis | Throughout NF stage 16 | gastrocoel roof plate
| rap1a | rap1, krev1, krev-1 | X.tropicalis | Throughout NF stage 28 | central nervous system spinal cord eye brain pharyngeal arch mandibular arch hyoid arch branchial arch somite
| rap2a | krev, rap2, k-rev, rbbp-30 | X.tropicalis | Throughout NF stage 3 (4-cell) | marginal zone blastomere
| rap2a | krev, rap2, k-rev, rbbp-30 | X.tropicalis | Throughout NF stage 16 | gastrocoel roof plate neural plate neural fold
| rap2a | krev, rap2, k-rev, rbbp-30 | X.tropicalis | Throughout NF stage 28 | eye brain forebrain midbrain hindbrain pharyngeal arch mandibular arch hyoid arch central nervous system spinal cord branchial arch otic vesicle
| rap2b | | X.tropicalis | Throughout NF stage 3 (4-cell) | blastomere
| rap2b | | X.tropicalis | Throughout NF stage 10 | marginal zone
| rap2b | | X.tropicalis | Throughout NF stage 16 | gastrocoel roof plate neural crest cranial neural crest non-neural ectoderm
| rap2b | | X.tropicalis | Throughout NF stage 28 | pharyngeal arch mandibular arch hyoid arch branchial arch posterior
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