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XB-IMG-171229

Xenbase Image ID: 171229


Figure S5. Related to Fig. 6; Developmental expression of Rapgef5 and Rap genes. In situ hybridization reveals rapgef5 mRNA is present from the earliest stages of development. It is detected in the animal pole at the 2 cell and 8 cell stages. In the stage 10 embryos expression appears diffuse around the blastopore. At stage 14 transcripts are detected in the anterior neural folds and forming GRP. rapgef5 expression is restricted to the anterior neural tube, brain, pharyngeal arches and cranial placodes at stage 28. rap1A, rap2A and rap2B are all expressed in the 4 cell embryo, in the gastrulating stage 10 embryo and in the GRP at stage 16. Expression of all three genes is also strong in the neural folds at stage 16, while rap2B also displays a speckled pattern on the lateral ectoderm. All three are expressed in the neural tube, brain, eye and pharyngeal arches at stage 28.

Image published in: Griffin JN et al. (2018)

Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V.

GeneSynonymsSpeciesStage(s)Tissue
rapgef5X.tropicalisThroughout NF stage 2 (2-cell)blastomere
rapgef5X.tropicalisThroughout NF stage 4 (8-cell)animal blastomere
rapgef5X.tropicalisThroughout NF stage 10 
rapgef5X.tropicalisThroughout NF stage 14gastrocoel roof plate
pre-chordal neural plate border
rapgef5X.tropicalisThroughout NF stage 28anterodorsal lateral line placode
epibranchial placode
glossopharyngeal epibranchial placode
facial epibranchial placode
central nervous system
spinal cord
pharyngeal arch
branchial arch
otic vesicle
rap1arap1, krev1, krev-1X.tropicalisThroughout NF stage 3 (4-cell)blastomere
rap1arap1, krev1, krev-1X.tropicalisThroughout NF stage 10 
rap1arap1, krev1, krev-1X.tropicalisThroughout NF stage 16gastrocoel roof plate
rap1arap1, krev1, krev-1X.tropicalisThroughout NF stage 28central nervous system
spinal cord
eye
brain
pharyngeal arch
mandibular arch
hyoid arch
branchial arch
somite
rap2akrev, rap2, k-rev, rbbp-30X.tropicalisThroughout NF stage 3 (4-cell)marginal zone
blastomere
rap2akrev, rap2, k-rev, rbbp-30X.tropicalisThroughout NF stage 16gastrocoel roof plate
neural plate
neural fold
rap2akrev, rap2, k-rev, rbbp-30X.tropicalisThroughout NF stage 28eye
brain
forebrain
midbrain
hindbrain
pharyngeal arch
mandibular arch
hyoid arch
central nervous system
spinal cord
branchial arch
otic vesicle
rap2bX.tropicalisThroughout NF stage 3 (4-cell)blastomere
rap2bX.tropicalisThroughout NF stage 10marginal zone
rap2bX.tropicalisThroughout NF stage 16gastrocoel roof plate
neural crest
cranial neural crest
non-neural ectoderm
rap2bX.tropicalisThroughout NF stage 28pharyngeal arch
mandibular arch
hyoid arch
branchial arch
posterior

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