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Figure S5. Related to Fig. 6; Developmental expression of Rapgef5 and Rap
genes. In situ hybridization reveals rapgef5 mRNA is present from the earliest stages
of development. It is detected in the animal pole at the 2 cell and 8 cell stages. In the
stage 10 embryos expression appears diffuse around the blastopore. At stage 14
transcripts are detected in the anterior neural folds and forming GRP. rapgef5
expression is restricted to the anterior neural tube, brain, pharyngeal arches and
cranial placodes at stage 28. rap1A, rap2A and rap2B are all expressed in the 4 cell
embryo, in the gastrulating stage 10 embryo and in the GRP at stage 16. Expression
of all three genes is also strong in the neural folds at stage 16, while rap2B also
displays a speckled pattern on the lateral ectoderm. All three are expressed in the
neural tube, brain, eye and pharyngeal arches at stage 28.
