Xenbase Image ID: 171269

Supplementary Figure 8. Activin/Nodal signaling is required for proper neural tissue formation in Xenopus. a, Expression of foxD5 at stage 13, N-tubulin at stage 15 and sox2 at stage 13 (left) and stage 25 (right) in control embryos and in embryos treated with 200µM SB505124 from midgastrula stage 11. Note the decreased intensity of neural marker gene expression in SB505124-treated embryos. Dorsal view for foxD5, N-tubulin and sox2 at stage 13 and stage 25 (right) and lateral view for sox2 at stage 25 (left). b, Expression of chd, myoD and sox2 at early neurula stage 14 in control embryos and in embryos treated with 800µM SB431542 from stage 11. Note the reduced neural plate in SB431542-treated embryos despite normal axial and paraxial mesoderm formation. Dorsal view for chd, myoD and sox2 (left), and anterior view for sox2 (right). Scale bar, 200µm. Image published in: Le Petillon Y et al. (2017) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Gene Synonyms Species Stage(s) Tissue foxd4l1.1.L foxd4, Foxd4l1, foxd4l1.1-a, foxd4l1.1-b, foxd5, foxD5a, FoxD5b, Xfd-12, XFlip, xlFoxD5a, xlFoxD5b, xtFoxD5 X. laevis Throughout NF stage 13 neuroectoderm neural plate tubb2b.L N-Tub, n-tubulin, NBT, neural beta-tubulin, NST, ntubulin, Xn-tubulin X. laevis Throughout NF stage 15 Rohon-Beard neuron neuroectoderm neural plate sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 13 neural plate pre-chordal neural plate sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 25 brain forebrain midbrain hindbrain neural tube neurogenic placode otic placode trigeminal placode optic vesicle Image source: Published Larger Image Printer Friendly View

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