Xenbase Image ID: 171273

Figure 6: Morpholino knockdown of ism1 in Xenopus laevis embryos results in clefting phenotypes. (A) Quantification of embryos injected with 24ng control morpholino (Ctrl MO) versus 24ng ism1 translation-blocking (ATG) MO shows craniofacial anomalies and clefting phenotypes in the ism1-altered group. (B) Faces of stage 43 embryos which are uninjected (top) or injected with 24ng ism1 ATG MO and exhibiting a cleft (bottom). Mouths have been outlined in red. (C) Phalloidin (red) and E-cadherin (green) staining to detect cell boundaries and epithelial cells, respectively, of the mouth of an uninjected (top) or 24ng ism1 ATG MO injected (bottom) embryos. Image published in: Lansdon LA et al. (2018) Copyright © 2018. This image is reproduced with permission of the journal and the copyright holder. This permission was brokered through the Copyright Clearance Centre (CCC). Larger Image Printer Friendly View

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