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Figure 5—figure supplement 2. Blocking MAPK or PI3K activation differentially alters animal pole explant gene expression (A–B) qRT-PCR analysis of animal cap explants treated with Meki (RDEA119) and cultured alongside sibling embryos collected at blastula stages (stage 9) (A) or treated with PI3Ki (LY294) and cultured alongside sibling embryos collected at early neurula stages (stage 13) (B).Blocking MAPK activation inhibits Snail1, FoxD3, Zic1, and Sox2 expression while blocking PI3K activation increases Zic2, Sox2, Sox3, Sox11, Sox17, and MyoD expression. (*p<0.05; **p<0.01). Image published in: Geary L and LaBonne C (2018) © 2018, Geary et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |