Xenbase Image ID: 171669

Figure 3. Bioinformatic analysis indicates that candidate plasticity proteins are enriched in processes related to protein translation, RNA splicing and chromatin remodeling.(A) Functional protein interaction networks of CPPs, shown as dots. Lines connecting CPP nodes represent protein interactions reported in the human (left) or mouse (right) STRING databases, with higher interaction confidence represented by thicker lines. CPPs belonging to the top biological processes in each network are color-coded: RNA splicing (red); chromatin remodeling (blue); and translation (green). (B) Fold changes in synthesis of all CPPs pertaining to RNA splicing, translation and chromatin remodeling, not restricted to those within the networks identified by STRING in (A), are color coded by average fold increase or decrease compared to control from 0.5 (blue) to 2.0 (red), indicated at the right. See also Supplementary file 4, which shows that pathways involved in RNA splicing and chromatin remodeling are statistically enriched for CPPs.10.7554/eLife.33420.009Figure 3—source data 1. Values of the fold changes in synthesis of all CPPs presented in Figure 3B. Image published in: Liu HH et al. (2018) © 2018, Liu et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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