Xenbase Image ID: 171718

Fig. 6. Functional mapping of proteins related to ICF syndrome. ZBTB24 stimulates transcription of CDCA7. CDCA7 associates with chromatin, recruits HELLS, and remodels nucleosomes to allow DNMT3b-mediated DNA methylation. CDCA7 ICF mutations inhibit chromatin binding and recruitment of HELLS to chromatin. Image published in: Jenness C et al. (2018) Copyright © 2018. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

Return to previous page