Xenbase Image ID: 172270

Fig 2. Celf1cKO/lacZKI mouse exhibits mis-expression of key lens genes.(A) Microarray heat-maps representing genes mis-regulated in Celf1cKO/lacZKI lenses compared to control (left column, ±2.5 fold-change, p<0.05, total 34 genes, indicated by heatmap color gradients (left columns: green, down in Celf1cKO/lacZKI; red, up in Celf1cKO/lacZKI) and their respective enrichment in normal lens compared to whole-embryonic tissue as per iSyTE (right columns, lens-enrichment in fold-change indicated by red color intensity). (B) Differentially expressed genes (DEGs) in Celf1cKO/lacZKI lenses are plotted on the X-axis as down-regulated (circles) and up-regulated genes (triangles). On the Y-axis, DEGs are separated based on their lens-enrichment. Red and green color gradients represent high and low lens-enrichment, respectively. Genes down-regulated in Celf1cKO/lacZKI lenses are predominantly highly-lens enriched, while those up-regulated do not exhibit this trend. Image published in: Siddam AD et al. (2018) © 2018 Siddam et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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