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Fig 6. Wnt activity during neural crest formation. (A) Dorsal view of a stage 12 Tg(pbin7Lef-dGFP) embryo hybridized with pax3 or gfp probes (posterior side is up). Dotted shapes delineate the presumptive neural border on both sides. Anterior view of a stage 12 Tg(pbin7Lef-dGFP) embryo hybridized with otx2 probe alone or otx2 and gfp probes together (dorsal side is up). (B) Dorsal view of a stage 14 Tg(pbin7Lef-dGFP) embryo hybridized with sox2 or gfp or both probes. Dotted shapes delineate the neural plate. The a and b dotted lines indicate the level of shown transverses sections. (C) Anterior views of a stage 18 Tg(pbin7Lef-dGFP) embryo first hybridized with probe against gfp and secondarily with probe against snai2. Dotted lines delineate gfp staining. (D) In situ hybridization against gfp on stage 21–22, 24–25, 26 and 29–30 Tg(pbin7Lef-dGFP) embryos (lateral views). For each stage, the dotted line indicates the level of the shown transverse section (a’-d’). ma: mandibular arch; nb: neural border; NC: migrating neural crest cells; np: neural plate; PSM: posterior presomitic mesoderm. Image published in: Borday C et al. (2018) © 2018 Borday et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 12 neuroectoderm otx2.L otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 12 anterior sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 14 neural plate snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 18 cranial neural crest Image source: Published Larger Image Printer Friendly View

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