Xenbase Image ID: 172475

Figure 6. Ouabain-sensitive currents in wild-type and mutant human Na/K pumps. (A–E) Mean ouabain-sensitive I-V plots in different ionic conditions from oocytes expressing wild-type (n = 5; A), L104R (n = 5; B), V332G (n = 5; C), delF100-L104 (n = 5; D), and EETA963S (n = 4; E) pumps, recorded 2–4 d after injection in experiments similar to those in Figs. 4 and 5. Shown are ouabain-sensitive currents in NMG+o (circles), NMG+o + 3 mM K+o (up triangles), Na+o (squares), and Na+o + 4.5 mM K+o (down triangles; symbol key in A). The insets in B–D show a zoomed-in view of the axes to illustrate the shift in reversal potential (VREV) when Na+o was replaced with NMG+o. (F) Mean reversal potential of ouabain-sensitive currents in NMG+o (solid bars) and Na+o (striped bars). Error bars represent SEM. Image published in: Meyer DJ et al. (2017) © 2017 Meyer et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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