Xenbase Image ID: 172617

Fig. 4. Anos1 is essential for the formation of cranial placodes and their derivatives. (A–D) Unilateral injection of anos1MO (40 ng) at the 2-cell stage causes a reduction/loss of expression of two pan-placodal genes, six1 (A) and foxi4.1 (B), as well as genes restricted to individual placodal domains such as dmrta1 (C) and pax8 (D). (E–G) Later in development, the injected embryos exhibited reduce dmrta1 (E), emx2 (F) and ebf2 (G) expression in the olfactory epithelium. (H–I) The expression of foxe1 in the developing pituitary was also reduced (I) as compared to sibling control (H). (A–I) Anterior views, dorsal to top. The injected side (arrowheads) is to the right. The percentage of affected embryos is indicated in the upper right corner of each panel. Image published in: Bae CJ et al. (2018) Copyright © 2018. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue six1.L XSix1 X. laevis Sometime during NF stage 14 to NF stage 17 anterior placodal area preplacodal ectoderm foxi4.L foxI1c, foxi4.1, xfd-10 X. laevis Sometime during NF stage 14 to NF stage 17 anterior placodal area preplacodal ectoderm dmrta1.L dmrt4, XDmrt4 X. laevis Sometime during NF stage 14 to NF stage 17 preplacodal ectoderm anterior placodal area pax8.L pax-8, XPax-8, XPax8 X. laevis Sometime during NF stage 14 to NF stage 17 preplacodal ectoderm foxe1.L ttf2 X. laevis Sometime during NF stage 14 to NF stage 17 preplacodal ectoderm adenohypophyseal placode dmrta1.L dmrt4, XDmrt4 X. laevis Sometime during NF stage 23 to NF stage 27 olfactory epithelium emx2.L emx-2, xemx2 X. laevis Sometime during NF stage 23 to NF stage 27 olfactory epithelium ebf2.L ebf2-a, ebf2-b, Mmot1, oe3, xcoe2, Xebf2 X. laevis Sometime during NF stage 23 to NF stage 27 olfactory epithelium foxe1.L ttf2 X. laevis Sometime during NF stage 23 to NF stage 27 adenohypophyseal placode Image source: Published Larger Image Printer Friendly View

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