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Fig. S1. Schematics of glycolysis. Glucose phosphorylation by hexokinase is the first irreversible step of glycolysis. The second and rate-limiting step of glycolysis is catalyzed by PFK1. This step is tightly controlled in cells, by the levels of Fructose-2.6-bisphosphate, potent allosteric regulator of PFK1. Fructose-2.6-bisphosphate is synthesized by PFKFB1-4 enzymes, which thus control the rate of glycolysis in the cells. PFKFB3 and PFKFB4, with a strong kinase activity over their phosphatase activity, promote Fructose-2.6-bisphosphate synthesis and stimulate glycolysis. In addition to their classic role in glycolysis regulation, recent unconventional roles of the PFKFB enzymes have been described in cancer or development (see text). Development 144: doi:10.1242/dev.157644: Supplementary information Development • Supplementary information Image published in: Figueiredo AL et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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