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Fig. S6. Glycolysis and PI3K-Akt signaling control neural crest migration. Glycolysis blockade (AJ) and PI3K-Akt blockade (K-T) during EMT and neural crest migration (stage 18 to stage 24) affects neural crest migration as shown by the expression of Sox9, Sox10 and Twist. Embryos rinsed at stage 24 and grown until stage 45 display craniofacial and eye development defects, albeit the presence of all individual cartilage elements. (A-C,F-H,K-M,P-R, U-W) Side views, anterior is to the left. (D,I,N,S,X) dorsal views st 45. (E,J,O,T,Y) Ventral views of alcian blue stained visceral cartilages, st 45. Scale bar= 500μm. Image published in: Figueiredo AL et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue sox10.L X. laevis Throughout NF stage 26 migratory neural crest cell cranial neural crest mandibular crest hyoid crest sox9.L cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 26 forebrain cranial neural crest mandibular crest hyoid crest otic placode optic vesicle migratory neural crest cell twist1.L twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 26 migratory neural crest cell cranial neural crest mandibular crest hyoid crest Image source: Published Larger Image Printer Friendly View

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