Xenbase Image ID: 172701

Fig. S7. Pfkfb4 is regulated by the neural crest gene regulatory network. Unilateral overexpression of members of the neural crest gene regulatory network modulates Pfkfb4 expression at mid and late neurula stages (stage 14 and 18, respectively). (A-D) Overexpression of WNT signals increases both Snail2 and Pfkfb4 expression. (E-H) FGF8 overexpression results in complete loss of pfkfb4, while snai2 is expanded. (I-L) BMP overexpression with a constitutively active form of BMPR1 results in loss of Snail2 and Pfkfb4 expression in the NC and ectopic expression in the neural plate. (M-T) PAX3 and TFAP2a positively regulate Pfkfb4 expression, similarly to Snail2. Dorsal views, anterior is to the top. Scale bar = 500μm. Image published in: Figueiredo AL et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 14 neural plate border neural crest snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 18 neural plate border neural crest pfkfb4.L X. laevis Throughout NF stage 14 neural plate border neural crest pfkfb4.L X. laevis Throughout NF stage 18 neural plate border neural crest Image source: Published Larger Image Printer Friendly View

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