Xenbase Image ID: 172765

FIGURE5 Zbtb14 coordinates the establishment of DV and AP axes in Xenopus. (a) By the early neurula stage, neural tissue is formed on the dorsal side of the embryonic ectoderm by BMP antagonists, and then regionalized into the future fore- , mid- and hindbrain and the spinal cord along the AP axis by posteriorizing signals such as Wnt. Zbtb14 promotes neural induction and inhibits epidermal differentiation by inhibiting BMP signaling, thereby regulating DV patterning. In addition, Zbtb14 promotes the formation of posterior neural tissues and suppresses anterior neural development by modulating Wnt signaling. (b) Mechanistically, Zbtb14 reduces the level of both total and phosphorylated Smad1/5/8 proteins to suppress BMP signaling and also induces an accumulation of β- Catenin to promote Wnt signaling by associating with Smurfs/I- Smads (Smad6 and Smad7) and β- TrCP, respectively. Zbtb14 plays a crucial role in the formation of DV and AP axes by regulating both the BMP and Wnt pathways during early Xenopus embryogenesis. Image published in: Takebayashi-Suzuki K et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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