Xenbase Image ID: 173167

Fig. 3 Cooperation of early ectodermal TFs in PPE and NC formation. a–d Cooperative effects of TFs as revealed in coinjection experiments. Significant differences are indicated (two-tailed Fisher’s exact test; *p < 0.05, **p < 0.001; ns: not significant). See Additional file 1: Tables S4 and S6 for numbers. e Reduction of TF expression in non-neural ectoderm after overexpression of Zic1 or Pax3. See Additional file 1: Table S7 for numbers. f, g Summary of regulatory interactions. Arrows indicate positive transcriptional regulation. Bars indicate negative transcriptional regulation. Solid lines are based on both loss and gain of function data, while hatched lines are supported only by gain of function data. Faint lines with question marks in g indicate potential alternative pathways for AP2 and Msx1/Dlx3. Image published in: Maharana SK and Schlosser G (2018) © Schlosser et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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