Xenbase Image ID: 173169

Fig. 5 Effects of Six1 overexpression on NPB markers and other ectodermal TFs. a–j Expression of PPE (Eya1, Sox3), NC (FoxD3), neural plate (Sox3) markers and early ectodermal TFs in dorsal views of neural plate stage Xenopus embryos after injection of Six1 mRNA. Anterior is to the bottom. Control side is shown on the left and injected side on the right (as indicated by red LacZ immunostaining). Arrowheads indicate expression domains on the control side. Reductions (arrows) and increased or ectopic expression domains (asterisks) in the neural (green) and non-neural ectoderm (orange) compared with the control side (arrowheads) are indicated. Insets show alternative phenotypes. k Summary of regulatory interactions. Arrows indicate ability of Six1 to promote expression of TFs. Bars indicate ability of Six1 to repress TFs. Faint colors indicate less frequent phenotypes. See Additional file 1: Table S9 for numbers. Image published in: Maharana SK and Schlosser G (2018) © Schlosser et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue eya1.L eyes absent-1, XEya1 X. laevis Sometime during NF stage 13 to NF stage 21 preplacodal ectoderm foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Sometime during NF stage 13 to NF stage 21 neural crest sox3.L Sry, Xlsox3, xSox3, Xtsox3 X. laevis Sometime during NF stage 13 to NF stage 21 preplacodal ectoderm neural plate zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Sometime during NF stage 13 to NF stage 21 neuroectoderm neural crest neural plate pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Sometime during NF stage 13 to NF stage 21 neural plate border neuroectoderm tfap2a.L ap2, AP2a, AP2alpha, tfap2a-a, tfap2a-b, tfap2alpha, XAP-2, xap2 X. laevis Sometime during NF stage 13 to NF stage 21 neuroectoderm neural plate border neural crest non-neural ectoderm msx1.L hox-7, hox7, msx-1, msx1-a, msx1-b, Xhox-7.1, Xmsx-1, xmsx1 X. laevis Sometime during NF stage 13 to NF stage 21 neural plate border anterior placodal area foxi4.2.L foxi1a, foxi4.2-a, foxi4.2-b, foxia, XFD2, Xfoxi1, Xfoxi1a, xlFox1a X. laevis Sometime during NF stage 13 to NF stage 21 preplacodal ectoderm dlx3.L ai4, dlx3-a, dlx3-b, tdo, Xdll-2, xdlx3 X. laevis Sometime during NF stage 13 to NF stage 21 non-neural ectoderm gata2.L GATA-2, xGATA-2, xgata2 X. laevis Sometime during NF stage 13 to NF stage 21 non-neural ectoderm Image source: Published Larger Image Printer Friendly View

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