Xenbase Image ID: 173209

Fig. 2: Nosip expression in early embryonic development of Xenopus laevis. A Animal (St. 1), anterior (St. 14, 20 and 23) and lateral (St. 9, 23, 32, 35 and 40) views are shown. Whole mount in situ hybridization (WMISH) experiments show a maternal nosip expression at stage 1 and 9 in the animal pole of the Xenopus embryo (black arrowheads). At stage 14 and 20, nosip transcripts are detected in the anterior neural plate including the eye field (red arrowhead) and the lateral plate border where the neural crest cells are induced (white arrowhead). At stage 23, nosip transcripts are visualized in the eye vesicle (red arrowheads and the migrating neural crest cells (white arrowheads). The dashed line shows the level of the transversal section in a. At stages 30 and 35, nosip is detected in the developing eye (red arrowheads) and the migrating neural crest cells (white arrowheads) of the mandibular (MA), branchial (BA) and hyoidal (HA) arches. B Compared expression of nosip and the two neural crest cell specific marker genes twist and snai2. nosip transcripts are detected in the lateral plate border at stage 14 where anterior neural crest cells are induced (dotted circles). At stage 20, nosip is expressed in the migrating neural crest cells positive for twist and snai2 (white arrowheads). Dotted circles highlight the cement glands. C Nosip expression is visualized in the neural crest of the mandibular (MA), branchial (BA) and hyoidal (HA) arches at stage 35 (horizontal section). At stage 40, nosip is expressed in the gills (middle panel, horizonal section; right panel, transversal section, white arroheads). D Compared expression of nosip and the two eye-specific marker genes prox1 and rax. The upper two rows represent transversal sections, the lower row horizontal sections. At stage 30, nosip is visualized in the lens (le) and the retinal (r) progenitor cells. At stage 35, nosip expression is detected in the lens and the retina with strongest level in the ciliary marginal zone (cmz). Image published in: Flach H et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue nosip.L X. laevis Sometime during NF stage 1 to NF stage 9 animal pole nosip.L X. laevis Throughout NF stage 14 pre-chordal neural plate optic field pre-chordal neural plate border nosip.L X. laevis Throughout NF stage 20 optic vesicle cranial neural crest nosip.L X. laevis Throughout NF stage 23 optic vesicle migratory neural crest cell cranial neural crest hyoid crest branchial crest nosip.L X. laevis Throughout NF stage 29 and 30 brain tail bud eye head cranial neural crest mandibular crest hyoid crest branchial crest anterior branchial crest posterior branchial crest spinal cord nosip.L X. laevis Throughout NF stage 35 and 36 eye head spinal cord mandibular arch hyoid arch branchial arch cranial neural crest nosip.L X. laevis Throughout NF stage 40 brain eye head branchial arch skeleton external gill twist1.L twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 14 cranial neural crest pre-chordal neural plate border twist1.L twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 20 migratory neural crest cell cranial neural crest mandibular crest hyoid crest branchial crest snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 14 pre-chordal neural plate border cranial neural crest snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 20 migratory neural crest cell cranial neural crest mandibular crest hyoid crest branchial crest prox1.L prospero, prospero homeobox protein 1, prospero-related homeobox 1, Prox 1, xprox1 X. laevis Sometime during NF stage 29 and 30 to NF stage 35 and 36 eye lens retina retinal neural layer rax.L rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Sometime during NF stage 29 and 30 to NF stage 35 and 36 eye retina ciliary marginal zone retinal neural layer Image source: Published Larger Image Printer Friendly View

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