XB-IMG-173213
Xenbase Image ID: 173213
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Fig. 6: Depletion of Nosip leads to reduced marker gene expression during eye
development.
A WMISH at stage 13 shows reduced expression of eye specific marker genes such
as rax and pax6 on the Nosip MO injected side (black arrowheads). In contrast, the
pan-neural marker gene sox3 is unaffected. Un-injected and Control MO injected
sides showed normal marker gene expression. Anterior views are shown. B
Statistical evaluation of data in A. C At stage 23, depletion of Nosip reduces the expression of the eye-specific marker genes rax, pax6 and otx2 (black arrowheads).
Un-injected and Control MO injected sides showed normal marker gene expression.
Anterior views are shown. D Quantification of the data in C. Abbreviations: N, number
of evaluated embryos in total; n, number of independent experiments, n.s., not
significant. Error bars visualize standard error of the means (s. e. m.); * p≤0.05. Pvalues
are calculated by a nonparametric, one-tailed Mann-Whitney rank sum test. Image published in: Flach H et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, John Wiley & Sons.
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