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Figure 7. Recurrent models of reticulospinal hdIN excitation and recruitment A, recurrent hexN network excited by single spikes in 30 sensory pathway DLCs with 5 hdINs to monitor output. B–D, responses to 30 DLC spikes. Raster plots show spike times for DLCs (black) and hexNs (colours); stimulus to DLCs at arrow. Lower panels show selected hdIN voltage records. The hexNs produce variable, summating EPSPs in hdINs (black arrowheads). EPSP summation can reach threshold (dashed red line) and lead to hdIN firing (red arrowhead) after variable delays. D, when hexN firing is brief, EPSPs sum but do not reach hdIN firing threshold (all five traces separated for clarity). E, histogram of all hexN firing times in 30 trials of a single network. F, model of a population of 30 hdINs with electrical coupling and feedback glutamate excitation (Hull et al. 2015) excited by hexN spikes at times determined by the hexN recurrent network model. G–I, overlapped voltage records of all 30 hdINs in response to hexN excitation in one trial. G, excitation can sum to threshold so hdINs are recruited to spike rhythmically and almost synchronously. H, in another trial the EPSPs sum but do not reach hdIN firing threshold (some traces separated for clarity). I, without electrical coupling, hdINs fire earlier and then asynchronously. All voltage scales as in B and G. Image published in: Koutsikou S et al. (2018) © 2018 The Authors The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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