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Figure 3. Loss of p2ry4 affected early neural development. Uninjected (a, d, g, j, m, p), TALEN‐L injected (b, e, h, k, n, q), and TALEN‐L/R injected (c, f, i, l, o, r) embryos were subjected to WISH for sox2 (a–f), otx2 (g–i), pax6 (j–l), rx1 (m–o), and krox20 (p–r) at early neurula stage. The expression of all the neural marker genes was reduced in TALEN‐L/R injected embryos. Dorsal (a–c, p–r) and anterior (d–o) views Image published in: Harata A et al. (2019) © 2018 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 14 neural plate otx2.L otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 14 pre-chordal neural plate pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 14 optic field neural plate rax.L rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 14 optic field egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 14 presumptive rhombomere Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + p2ry4 TALEN + NF14 (in situ hybridization) Fig. 3 o Expression Phenotype decreased amount rax.L expression in optic field Xla Wt + p2ry4 TALEN + NF14 (in situ hybridization) Fig. 3 c f Expression Phenotype decreased amount sox2.L expression in neural plate Xla Wt + p2ry4 TALEN + NF14 (in situ hybridization) Fig. 3 i Expression Phenotype decreased amount otx2.L expression in pre-chordal neural plate Xla Wt + p2ry4 TALEN + NF14 (in situ hybridization) Fig. 3 l Expression Phenotype decreased amount pax6.L expression in optic field Xla Wt + p2ry4 TALEN + NF14 (in situ hybridization) Fig. 3 r Expression Phenotype decreased amount egr2.L expression in presumptive rhombomere Larger Image Printer Friendly View

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