Xenbase Image ID: 173285

Fig. 4. Effects of Otx2 mutants on eye marker genes. Embryos were co-injected on the right side with mRNA for globin, WT, 4E or 4A (20 pg/embryo) and nbgal as described in the legend to Fig. 3, and were subjected to WISH for rax (A-D), pax2 (E-H) and pax6 (I-L) at early neurula stages (stages 13- 14, A-D) or late neurula stages (stages 18-20, E-L). The fractions indicate the proportion of the presented phenotype per total number. Colors of numbers: white indicates normal expression; magenta indicates upregulation; blue indicates downregulation; orange indicates combined effects of enlarged Di and reduced OV. Square brackets indicate the sizes of the eye field showing the difference between left and right. Open arrowhead indicates the position of MHB. Anterior view with dorsal up. (I′-L′) Enlarged images of I-L. Dashed black and white lines indicate Di and OV, respectively, where pax6 is expressed. Colors of arrowheads: white indicates normal expression; magenta indicates upregulation; blue indicates downregulation (A-L′). Scale bars: 500 μm in A-L; 100 μm in I′-L′. Image published in: Satou Y et al. (2018) Copyright © 2018. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue rax.L rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Sometime during NF stage 13 to NF stage 14 optic field pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Sometime during NF stage 18 to NF stage 20 optic vesicle neural tube pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Sometime during NF stage 18 to NF stage 20 presumptive midbrain-hindbrain boundary neural plate preplacodal ectoderm Image source: Published Larger Image Printer Friendly View

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