Xenbase Image ID: 173341

Fig. 4. gli2 requirement for the maintenance of NC specification. (B–E, G–J, M–N) Dorsal views of Xenopus laevis embryos at midneurula stage; anterior side is on the left. Arrowheads indicate the injected or implanted side. (A–E) GANT61 injection at stage 3 produces a decrease in the expression of foxd3 and snail2, with a concomitant increase in the expression of sox2 and xk81a. (F) Quantification of phenotypes in the injected embryos of figures B–E. (G–J) Injection of the GANT61 diluent (DMSO 0,03%) produced no changes in the expression of the gene markers analyzed. (K) Quantification of phenotypes. (L–O) Implanted GANT61-soaked beads from stage 12.5 to 16 produced a reduction in foxd3 expression, as opposed to the implantation of DMSO-soaked beads. (P–R) NC explants with mesoderm incubated in GANT61 from stage 14–18 lose foxd3 expression. Image published in: Cerrizuela S et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Sometime during NF stage 15 to NF stage 16 neural crest snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Sometime during NF stage 15 to NF stage 16 neural crest sox2.S anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Sometime during NF stage 15 to NF stage 16 neural plate krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Sometime during NF stage 15 to NF stage 16 epidermis Image source: Published Larger Image Printer Friendly View

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