XB-IMG-173347
Xenbase Image ID: 173347
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Fig. 10. gli2 epistatic relationships with ihh, gli3, ednra and eg5. (A) Schematic representation of the experiments performed. (B–Q) Dorsal views of Xenopus laevis embryos at mid-neurula stage; anterior side is on the left. Arrowheads indicate the injected side, shown in turquoise. The images show combinatorial experiments performed to evaluate the epistatic relationship between gli2 and different genes involved in the gene regulatory network that induces the NC. They also show the effect of individual genes on the NC. (B–E) gli2 is downstream of ihh during NC induction. (F–I) gli2 and gli3 rescue each other's deficiency during NC induction. (J–Q) Both genes ednra and eg5 act upstream of the gli2 transcription factor during NC induction and specification. (R) Quantification of the phenotypes shown in B–Q. (S) Hierarchy diagram plotting the epistatic relationships between the genes analyzed. Image published in: Cerrizuela S et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V.
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