XB-IMG-173443
Xenbase Image ID: 173443
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Figure 7. Id genes orchestrate cardiogenic mesoderm
differentiation in vertebrates. Id genes control the activation
of the cardiogenic mesoderm differentiation program
in mesendoderm progenitors by inhibiting the
activity of repressors (Tcf3 and Foxa2) while promoting
the expression of activators of cardiogenic mesoderm differentiation
(Evx1, Grrp1, and Mesp1). The Id-controlled
network induces cardiogenic mesoderm (Mesp1 and Kdr)
differentiation from pluripotent cells. Id1-induced CMPs
generated from pluripotent stem cells are cryopreservable
and spontaneously form contracting cardiomyocytes
(∼70%) as well as vascular endothelial cells,
smooth muscle, and fibroblasts. Image published in: Cunningham TJ et al. (2017) Copyright © 2017. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View |