XB-IMG-173477
Xenbase Image ID: 173477
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Fig. 2 Overexpression of atf4 interferes with neurogenesis and
eye anlage formation
(A-C) Lateral view of the embryos showing dose-dependent effects of atf4
on eye development. (D-N) Effects of atf4GR on the expression of various
neural marker genes. The injected sides are on the right. Dexamethasone was
added at stage 12.5. (D, F, H, J, L−N) Anterior views. (E, G, I, K) Dorsal
views of D, F, H, and J, respectively. The white triangles in D, F, and H
highlight the missing of marker gene expression in the lens placode, trigeminal
ganglion, and placode on the injected side, respectively. The red dashed lines
in L, M, and N illustrate the midline of the embryos. Dex, dexamethasone. The
statistics for the phenotype are as follows: sox3 (19/20), N-tubulin (20/24),
pax2 (32/34), pax6 (20/20), otx2 (18/21), six3 (16/18), rx1 (12/14). Image published in: Liu JT et al. (2011) Copyright © 2011. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |