Xenbase Image ID: 173486

Figure 2: Systematic Analysis of the Knockdown Phenotypes of G-Protein Alpha Subunits and their Interaction with Polycystin-1. (A-O) Whole mount in situ hybridization for Nbc1 expression comparing embryos lacking individual G-protein alpha subunits or combinations thereof. Representative images are shown. Loss-of-Nbc1 expression in the late distal tubule is indicated by red arrowheads. (P) Table summarizing the phenotypes of Xenopus embryos lacking G-protein alpha subunits either individually or in combinations. Morphants with a PKD phenotype are highlighted in gray. Pan Gnaq-MO stands for the knockdown of the entire Gnaq family by simultaneous injection of Gnaq-MO, Gna11-MO, Gna14-MO1+2 and Gna15-MO. The data are presented as percentages of at least three biological replicas. Image published in: Zhang B et al. (2018) Copyright © 2018. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue slc4a4.L hhNMC, hnbc1, nbc1, nbc2, nbce1, pNBC, slc4a5, XNBC1 X. laevis Throughout NF stage 39 late distal tubule late proximal tubule pronephric tubule Image source: Published Larger Image Printer Friendly View

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