Xenbase Image ID: 173547

Figure 1 From: Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes. Genes of Ras-dva family of small GTPases were eliminated during vertebrates’ evolution. (A) Schematic version of the phylogenetic tree (full version see at Supplementary Fig. S1) of Ras-dva small GTPases and nearest groups of small GTPases, Ras, Rho, Rab etc. All vertebrate’s Ras-dva proteins form a separate bunch (bootstrap 94). The nearest homologs (41% of homology) are invertebrate small GTPases. (B) Scheme of Ras-dva genes elimination during vertebrates’ evolution. The presence of Ras-dva1 or Ras-dva2 genes in different classes is marked by “plus”, absence - by “minus”. The gray triangle demonstrates the tendency of impairment in regenerative ability during the evolution. Oblique cross indicates the loss of Ras-dva1 or Ras-dva2 gene. Notably, lack of Ras-dva genes correlates with the regenerative capacity decrease. Drawings were done by M.B.T. Image published in: Ivanova AS et al. (2018) © The Author(s) 2018. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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