XB-IMG-173552
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Figure 6
From: Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes. Down-regulation of Ras-dva genes by vivo-morpholino oligonucleotides inhibits the D. rerio fin regeneration. (A–D) Transmitted light images of regenerating D. rerio caudal fins injected in the right half by control vivoMO (A), dRas-dva1 vivoMO (B), mis-dRas-dva1 vivoMO (C) or dRas-dva2 vivoMO (D) at 3 dpa. Red dashed line indicates amputation level. Distal is upside, dorsal is to the left. Scale bar 200 µm. (E) Regeneration efficiency is calculated as normalized area of regenerated part of the caudal fin at 3 dpa injected by vivoMO divided by the normalized area of regenerated part that was not injected. Resulting values were taken as a percentage of the value obtained for control vivoMO. The scheme demonstrates how normalized length value Image published in: Ivanova AS et al. (2018) © The Author(s) 2018. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |