Xenbase Image ID: 173946

Fig. 4 Similarities and differences in developmental cell state hierarchies and gene expression between frog and fish. (A) Xenopus and Zebrafish cell state trees aligned by orthologous cell states (red shading). Gray/white stripes provide a visual guide. (B) Single-cell visualization of matched epidermal subtrees in frog and fish showcase similarities and differences in developmental hierarchy. SCC, small secretory cell; NE, neuroendocrine cell. Unidentified zebrafish cell types are labeled by marker genes. (C) Ortholog genes across species have variable conservation of cell state specific expression. Just 30% of self-similar orthologs are conserved at a 95% FDR compared to random gene pairs. Right panels: examples of highly (Sox2) and poorly (Gata5) correlated TFs across species. (D and E) Function, not sequence, predicts gene expression conservation: (D) Orthologs with highly conserved expression patterns across species are enriched in TF-associated GO terms. P-values show Bonferroni-corrected binomial test results. (E) Protein sequence conservation is not correlated with gene expression conservation (r = 0.01; P = 0.6). Image published in: Briggs JA et al. (2018) Copyright © 2018. Reprinted with permission from AAAS. Readers may view, browse, and/or download this image for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from the publisher. Larger Image Printer Friendly View

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