XB-IMG-173954
Xenbase Image ID: 173954
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Fig. 10.
A C-terminal domain of Bix1 acts in cis to prevent induction of apoptosis; the N terminus of Bix3 does not possess this activity. Threonine 384 is necessary for the anti-apoptotic function of the Bix1 C-terminal region. (A) A chimeric form of Bix1, in which the 45 C-terminal amino acids are derived from Bix3, induces apoptosis. (B) Comparison of the 45 C terminal amino acids of Bix1 and Bix3. (C) Mutation of threonine 384 of Bix1 to alanine causes the protein to acquire apoptosis-inducing activity, as does mutation of the two glutamic acids of the DWEEN motif. Image published in: Trindade M et al. (2003) Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |