XB-IMG-173997
Xenbase Image ID: 173997
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Figure 1: Wdr5 depletion alters left-right patterning in Xenopus tropicalis.
(a, b) Percentage of embryos that have abnormal (a) pitx2 or (b) dand5 expression. Embryos
were injected at the one-cell stage or in one cell at the two-cell stage with wdr5 MO. L, left;
R, right; Bilateral: signal present on both sides; Absent, signal absent on both sides;
Reduced: signal reduced on both sides.
(c, d, e, f, g) Percentage of embryos that have abnormal pitx2 expression. Embryos were
injected at the one-cell stage with (c) scrambled MO, (d) wdr5 MO, wdr5 MO + human
WDR5-3xGFP, scrambled MO injected on the right or left side of embryos, (e) Second wdr5
MO, (f) wdr5 MO, wdr5 MO + K7Q-WDR5-3XGFP, or K7Q-WDR5-3XGFP, or (g) wdr5 MO
and wdr5 MO + human 26-334-3xGFP.
Experiments were repeated 3 times. ‘n’ = number of embryos. ★, ★★ and ★★★ indicate P <
0.05, P < 0.005 and P < 0.0005. Image published in: Kulkarni SS and Khokha MK (2018) Copyright © 2018. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |