Xenbase Image ID: 174539

Figure 2. GRP patterning is defective in fgfr4 CRISPR mutants. Most representative expression patterns of pre-somitic GRP markers coco, xnr1, and gdf3 in stage 17 (A,C,E) and stage 19 (B,D,F). GRPs of control and fgfr4 F0 CRISPR animals; ventral view of GRPs, anterior is to the top. Graphs show percentages of embryos with differential expression patterns of coco, xnr1, and gdf3. **p < 0.01, ***p < 0.001, ****p < 0.0001. Image published in: Sempou E et al. (2018) Copyright © 2018 Sempou, Lakhani, Amalraj and Khokha. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue dand5 51-B6, cer2, cerl2, charon, cktsf1b3, coco, crl2, dante, grem3, S10-51-B6, xCoco X. tropicalis Throughout NF stage 17 left-right organizer nodal1 nodal, nodal-related 1, nr1, nr1-a, spaw, Xnr-1, Xnr1 X. tropicalis Throughout NF stage 17 left-right organizer nodal1 nodal, nodal-related 1, nr1, nr1-a, spaw, Xnr-1, Xnr1 X. tropicalis Throughout NF stage 19 left-right organizer dand5 51-B6, cer2, cerl2, charon, cktsf1b3, coco, crl2, dante, grem3, S10-51-B6, xCoco X. tropicalis Throughout NF stage 19 left-right organizer gdf3 derriere, derriére, gdf-3, gdf1, vgr-2, vgr2 X. tropicalis Throughout NF stage 17 left-right organizer gdf3 derriere, derriére, gdf-3, gdf1, vgr-2, vgr2 X. tropicalis Throughout NF stage 19 left-right organizer Image source: Published Experiment + Assay Source Phenotypes and Disease Xtr Wt + fgfr4 CRISPR + NF17 (in situ hybridization) Fig. 2 A Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount dand5 expression in left-right organizer Xtr Wt + fgfr4 CRISPR + NF19 (in situ hybridization) Fig. 2 B Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount dand5 expression in left-right organizer Xtr Wt + fgfr4 CRISPR + NF17 (in situ hybridization) Fig. 2 C Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount nodal1 expression in left-right organizer Xtr Wt + fgfr4 CRISPR + NF19 (in situ hybridization) Fig. 2 D Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount nodal1 expression in left-right organizer Xtr Wt + fgfr4 CRISPR + NF17 (in situ hybridization) Fig. 2 E Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount gdf3 expression in left-right organizer Xtr Wt + fgfr4 CRISPR + NF19 (in situ hybridization) Fig. 2 F Disease congenital heart disease visceral heterotaxy Expression Phenotype decreased amount gdf3 expression in left-right organizer Larger Image Printer Friendly View

Return to previous page