Xenbase Image ID: 174569

Fig. 1. Schematic overview of the Xenopus tumor/minor H-Ag transplantation system. Several syngeneic clones produced gynogenetically from X. laevis × X. gilli hybrids have been MHC typed. While some have different MHC haplotypes (e.g., LG-3 [b/d]) and LG6 [a/c]), others share the same MHC haplotype but express different minor H-loci (LG-6 and LG-15). On the left side, skin grafts exchanged among individuals of the same LG-15 isogenetic clone are not rejected (top), whereas skin grafts on individuals of the LG-6 clone that is MHC identical with LG-15 but differs at minor H-loci are rejected significantly more slowly (middle) than are MHC-disparate allografts (bottom). On the right side, the 15/0 tumor is tumorigenic when transplanted in the clone from which it derives (LG-15, top), as well as MHC identical but minor H-Ag–disparate LG-6 clone, but is rejected in the MHC-disparate LG-3 host. For abbreviations, see list. Image published in: Robert J and Ohta Y (2009) Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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