XB-IMG-174608
Xenbase Image ID: 174608
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Fig. 10. Proposed model showing the multiple roles of Lif signaling in Xenopus embryo from gain of function and the use of dominant negative of its receptor. Lif is involved in tumor-like formation, ventralization, head and kidney formation through the use of three distinct signaling pathways: STAT3 activation (P-STAT3), PI3K and MAPK. Data from this study are figured in blue. Data from literature are figured in red. Lif activates STAT3 target genes like the oncogenes fos, jun and myc that can contribute to tumor-like formation. Lif activates the expression of BMP effectors msx1 and ventx1/2 that are known to ventralize the embryo. Ventralisation can also depend on STAT3 activation independently of BMP (Nishinakamura et al., 1999). P-STAT3 may also activate BMP gene expression (Fukuda et al., 2007). Lif repress cerberus, DKK and IGF that are required for head development (Glinka et al., 1997, Glinka et al., 1998, Pera et al., 2001). Lif signaling hindrance leads to wt1 decrease and normal kidney formation. Image published in: Jalvy S et al. (2019) Copyright © 2019. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |