XB-IMG-174822
Xenbase Image ID: 174822
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Fig. S5. Simulation of hypothetical genes expressed in the order of temporal collinearity.
Simulation of the time course of de novo expression of two or three hox genes 1 (magenta), 2 (blue), and 3 (yellow) in two tissues (X and Y, left and middle panels) and in the whole embryo (the sum of tissues X and Y, right panels) are depicted, assuming genes start expression in the order according to the temporal collinearity hypothesis, from gene 1 to 3 (anterior to posterior), and expression starts in tissue X earlier than tissue Y. x-axis, time (t); y-axis, the number of transcripts (normalized by the highest value as 1); vertical arrows in left and middle panels, the late expression in tissue X or Y compared to the other; oblique arrows in the right-most panel, the start point of cumulative expression (thick lines); solid horizontal lines, a detectable number of transcripts; dashed horizontal lines, detection limits; asterisks, the crossing point of transcript number between genes.
(A) Simple monotonous increment of de novo transcripts in all genes. The anterior
gene 1 always reaches a detectable number (horizontal lines) earlier than the posterior gene 2. (B) Non-monotonous increment of de novo transcripts in tissue Y. In tissue Y, the order to reach a higher number (a) is reversed after the crossing point (asterisks) than a low number (b). This is the same in a whole embryo (c vs d). (C) Different timing of initial transcription of three genes in tissues X and Y. The three genes in tissue Y start to be transcribed between the start of expression of gene 1 and 2 in tissue X. In the whole embryo, the order that gene transcripts reach a high number (e) or a lower number (f) are the same, matching the order of genes. Image published in: Kondo M et al. (2019) © 2019. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |