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 Fig. 8. A model of Tbx2-mediated ectodermal specification. Tbx2 binds to and represses target genes in animal pole progenitor cells, thereby inhibiting mesoderm and endoderm formation. In the marginal zone and vegetal pole, other T-box proteins bind to and activate an overlapping set of target genes, stimulating mesodermal and endodermal differentiation.

Image published in: Teegala S et al. (2018)

Copyright © 2018. Image reproduced with permission of the Publisher, John Wiley & Sons.

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