Xenbase Image ID: 174951

Fig. 2. SoxE factors interference with pluripotency gene expression depends upon DNA-binding capabilities.(A)In situhybridization examiningVent2,Oct25,Id3, andTF-AP2 in blastula stage (stage 9) embryos injected unilaterally with Sox2, Sox3, Sox9 or Sox10. (B) Quantification of phenotypes associated with SoxB1 and SoxE factor overexpression(C) Schematic of Sox9 and Sox10 protein domains. (D)In situ hybridization examining Vent2 and Id3 expression in blastula stage (stage 9) embryos injected unilaterally with wildtype or mutant forms of Sox9. (D)In situ hybridization examining Vent2 and Id3 expression in blastula stage (stage 9) embryos injected unilaterally with wildtype or mutant forms of Sox10. (E)Quantification of phenotypes associated with overexpression of SoxE factors and SoxE functional variants. Asterisk (*) denotes injected side of the embryo as marked by staining of the lineage tracerβ-galactosidase (red) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) Image published in: Buitrago-Delgado E et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue ventx2.2.L vent-2, vent2, Xom, xvent-2, xvent2 X. laevis Throughout NF stage 9 animal hemisphere pou5f3.2.L Oct-25, oct25, pou25, xoct-25, xoct25 X. laevis Throughout NF stage 9 animal hemisphere id3.L heir-1, id3-a, id3-b, xid3, xidia, xIdx X. laevis Throughout NF stage 9 animal hemisphere tfap2a.L ap2, AP2a, AP2alpha, tfap2a-a, tfap2a-b, tfap2alpha, XAP-2, xap2 X. laevis Throughout NF stage 9 animal hemisphere Image source: Published Larger Image Printer Friendly View

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