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Fig. 3. Inducing SoxB1 and SoxE protein activities at gastrulation leads to differential effects on neural crest formation, but similar effects on the epidermis.(A)Schematic of experimental overview. (B)In situ hybridization assaying expression of neural crest factors Snai2, FoxD3, and Sox10 in neurula (stage 15) embryos injected with inducible Sox2, Sox3, Sox9, or Sox10 constructs. (C)In situ hybridization assaying the expression of epidermal factor EPKin neurula (stage 15) embryos injected with inducible Sox2, Sox3, Sox9, or Sox10 constructs. (D) Quantification of phenotypes associated with overexpression of inducible SoxB1 and SoxE factors. Asterisk (*) denotes injected side of the embryo as marked by staining of the lineage tracer β-galactosidase (red). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) Image published in: Buitrago-Delgado E et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 15 neural crest neural plate border foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 15 neural crest neural plate border sox10.L X. laevis Throughout NF stage 15 neural crest neural plate border krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Throughout NF stage 15 epidermis Image source: Published Larger Image Printer Friendly View

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