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Fig. 4. Overexpression of SoxB1 or SoxE factors impairs the formation of mesoderm and endoderm in animal pole explant assays.(A) Schematic of experimental overview. (B)In situ hybridization examining Brachyury expression in animal pole explants injected with Sox2, Sox3, Sox9 or Sox10 mRNA and cultured with or without a low dose of activin. (C)In situhybridization examiningSox17expression in animal pole explants injected with Sox2, Sox3, Sox9 or Sox10 mRNA and cultured with or without a high dose of activin.(D) Quantification of induction potential following SoxB1 or SoxE factor overexpression in morphant animal caps. Image published in: Buitrago-Delgado E et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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