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Fig. 6. SoxE factors cannot fully replace the function of SoxB1 factors in animal pole explants induced to a neuronal lineage.(A) Schematic of experimental overviewfor knockdown experiments. (B)In situ hybridization examining Sox2 expression in animal pole explants injected with Sox2 and Sox3 morpholino and chordin. (C)In situhybridizationexamining Sox3 expression in animal pole explants injected with Sox2 and Sox3 morpholino and chordin. (D) Schematic of experimental overview for rescue experiments. (E)In situ hybridization examining Sox11 expression in animal pole explants injected with Sox2 and Sox3 morpholino, chordin, and either Sox2 or Sox9 mRNA. (F)In situhybridization examining Sox11 expression in animal pole explants co-injected with Sox2 and Sox3 morpholino, chordin, and either Sox3 or Sox10 mRNA. (G) Quantification of induction potential following SoxB1 and SoxE factor overexpression in morphant animal caps Image published in: Buitrago-Delgado E et al. (2018) Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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