Xenbase Image ID: 175201

Fig. 8. Wnt11a signaling acts downstream of Dkk1 during early cardiogenesis. A. Front view of stage 28 embryos showing the reduced expression of wnt11a and alcam upon unilateral Dkk1 knockdown (black arrow). White dotted lines indicate the cement gland. B. Co-injection of Dkk1 MO with alcam restored the expression of cardiac marker genes (black arrow) at stage 28. C. Co-injection of Dkk1 MO with wnt11a rescued the expression of cardiac marker genes (black arrow) at stage 28. D. Reduced expression of wnt11a by Dkk1 MO injection is restored by inhibiting Wnt/β-catenin signaling. Quantifications are shown next to the image of the embryos. Black dotted lines indicate the cement gland. n = number of independent experiments, N = total number of embryos analyzed. Mean values with standard errors are given. *p < 0.05, **p < 0.01 with Mann-Whitney rank sum test. Image published in: Guo Y et al. (2019) © 2019 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Gene Synonyms Species Stage(s) Tissue wnt11.L Wnt11-R, WNT11-related, wnt11a, Wnt11r X. laevis Throughout NF stage 28 heart primordium alcam.L cd166, DM-GRASP, MGC83026 X. laevis Throughout NF stage 28 heart primordium myh6.L aMHC, ck231, MHC, MHC-alpha, MHCa, MHCalpha, muz, muzak, XCMHC X. laevis Throughout NF stage 28 heart primordium tbx5.L tbx-5, tbx5-a, tbx5-b, xtbx-5, xtbx5 X. laevis Throughout NF stage 28 heart primordium Image source: Published Larger Image Printer Friendly View

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